DOI: 10.24019/issn.2532-0831

Online ISSN 2532-0831

Journal of Theoretical and Applied Vascular Research

Journal website: http://www.vasculab.eu/jtavr.xml

JTAVR 2024;09(1):25-29

Lymphatic senescence and possible clinical implications

A Onorato¹, SL Filelfi², N Goswami²

Abstract Lower limb edema is a frequent occurrence in the geriatric age. Among the possible causes, the deterioration of lymphatic function caused by its senescence is usually overlooked. There is multiple evidence of aging of the lymphatic system, based on in vivo observations, both in humans and in animal models, and on cadavers. The alterations concern both the morphological and ultrastructural level, as well as functionality. On the basis of the available data, some clinical pictures can be better understood and new areas of investigation envisaged.