DOI: 10.24019/issn.2532-0831

Online ISSN 2532-0831

Fondazione Vasculab ONLUS

Journal of Theoretical and Applied Vascular Research


Journal website: http://www.vasculab.eu/jtavr.xml


JTAVR 2016;1(1):45-49

JTAVR

Theoretical approach of ductal morphogenesis

Author

M Montévil*, C Sonnenschein**, AM Soto***

*Laboratoire "Matière et Systèmes Complexes" (MSC), UMR 7057 CNRS, Université Paris 7 Diderot, 75205 Paris Cedex 13, France and Institut d'Histoire et de Philosophie des Sciences et des Techniques (IHPST) - UMR 8590 Paris, France. Email: mael.montevil@gmail.com. Url: http://montevil.theobio.org
**Centre Cavaillès, École Normale Supérieure, Paris, France, and Institut d'Etudes Avancees de Nantes, France and Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA USA.
***Centre Cavaillès, République des Savoirs, CNRS USR3608, Collège de France et Ecole Normale Supérieure, Paris, France and Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA USA
submitted: Jul 12, 2016
accepted Sep 6, 2016
EPub ahead of Print: Nov 30, 2016
Published: Dec 31, 2016
Abstract We developed 3D culture methods that reproduce in vitro mammary gland ductal morphogenesis. We are proposing a conceptual framework to understand morphogenetic events based on epistemologically sound biological principles instead of the common practice of using only physical principles. More specifically, our theoretical framework is based on the principle that the default state of cells is proliferation with variation and motility. We emphasize the role played by the agency of cells embedded in a gel and the circularity that is relevant for the intended process, whereby cells act upon other cells and on matrix elements, and are subject to the agentivity of neighboring cells. This circularity strongly differs from classical linear causality. Finally, our approach opens up the study of causal determination to multilevel explanations rather than to reductive ones involving only molecules in general and genes in particular.
Keywords Morphogenesis, extracellular matrix, theoretical principles, default state of cells, modelization.
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Full text - DOI: 10.24019/jtavr.7 - Corresponding author: Dr. Maël Montévil, EMail mael.montevil@gmail.com

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